Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation

Neisseria meningitidis, pathogenetic mechanisms to overcome the human immune defences.

Neisseria meningitidis is hosted only by humans and colonizes the nasopharynx; it survives in the human body by reaching an equilibrium with its exclusive host. Indeed, while cases of invasive disease are rare, the number of asymptomatic Neisseria meningitides carriers is far higher. The aim of this paper is to summarize the current knowledge of survival strategies of Neisseria meningitides aga...

Human immune response to iron-repressible outer membrane proteins of Neisseria meningitidis.

Neisseria meningitidis grown under iron-limiting conditions in vitro expresses additional iron-repressible outer membrane proteins (FeRPs). To see which FeRPs were expressed and immunogenic in human infection, we examined purified membranes from four meningococcal disease isolates with Western blotting of patient sera. Convalescent serum from each patient contained immunoglobulin G (IgG) and Ig...

Functional diversity of three different DsbA proteins from Neisseria meningitidis.

The genome of Neisseria meningitidis serogroup B strain MC58 contains three genes - nmb0278, nmb0294 and nmb0407 - encoding putative homologues of DsbA, a periplasmic thiol disulphide oxidoreductase protein-folding catalyst of the Dsb protein family. DsbA assists the folding of periplasmic and membrane proteins in diverse organisms. While all three cloned genes complemented the DTT sensitivity ...

Transferrin-binding proteins of Neisseria meningitidis

Fulminant Supraglottitis from Neisseria meningitidis

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